TravelMedEvidence. Expertise. Safer travel.
/
All countries
🇨🇫

Central African Rep.

Central Africa · Africa · Physician brief

📝Draft — pending physician review
📝Draft — pending physician review. This brief was compiled from CDC, WHO, and EKRM/HealthyTravel sources (June 2026) and has not yet been verified by a clinician. Confirm specifics with a travel-medicine professional before relying on it.

Security situation — check travel advice before booking

The Central African Republic experiences armed conflict, banditry, and major restrictions on movement; medical and evacuation capacity is extremely limited. The Swiss FDFA advises against travel to most of the country. Consult current FDFA travel advice and arrange comprehensive evacuation insurance before any trip.

Swiss FDFA / EKRM · Updated 2026

Yellow fever vaccination certificate required for entry

The Central African Republic requires proof of yellow fever vaccination for all arriving travelers aged 9 months and older. Carry your International Certificate of Vaccination (yellow card). The vaccine must be given at least 10 days before arrival to be valid, and in Switzerland is only available at approved yellow-fever vaccination centres.

CDC / WHO IHR yellow fever requirements · Updated 2026

Meningitis belt — dry season risk

The Central African Republic sits in or adjacent to the African meningitis belt, where meningococcal disease risk rises during the dry season (roughly December to June). Meningococcal vaccination (ACWY) is recommended, especially for longer stays or close contact with the local population.

CDC / EKRM · Updated 2026

Malaria

High

Dengue

Low

Yellow fever

High

Chikungunya

Low

Vaccines

VaccineRecommendationReference
Routine vaccines

Make sure you are up-to-date on all routine vaccines before every trip — per the Swiss BAG schedule. These include:

BAG Impfplan
Cholera

CDC reports no current active cholera transmission and the vaccine is generally not recommended; reassess if an outbreak is declared or for high-risk humanitarian/healthcare work.

CDC Yellow Book
Hepatitis A

Recommended for all travelers. Note for Swiss travelers: Hepatitis A is not part of the routine Swiss BAG childhood schedule, so most adult travelers will need vaccination.

CDC Yellow Book
Hepatitis B

Recommended for unvaccinated travelers. Routine in the Swiss childhood schedule since 1998, so younger travelers are usually covered; older travelers should check their status.

CDC Yellow Book
Meningococcal

Recommended (ACWY) for travel during the dry season (December–June), and for longer stays or close local contact, given proximity to the meningitis belt.

CDC Yellow Book
Rabies

Rabid dogs are common and post-exposure treatment is rarely available outside larger urban facilities. Pre-exposure vaccination is recommended for long stays, remote travel, cyclists/bikers, animal workers, and young children.

CDC Yellow Book
Typhoid

Recommended for most travelers given widespread food and water exposure, especially those visiting rural areas, staying with friends or relatives, or on longer trips.

CDC Yellow Book
Yellow fever

Required for entry (certificate checked, ≥9 months) AND medically recommended — the country is yellow-fever endemic. Single dose gives lifelong protection; must be given ≥10 days before arrival. In Switzerland, available only at approved yellow-fever vaccination centres.

CDC Yellow Book

Disease-specific guidance

Malaria

High

High risk in all areas year-round, including the capital Bangui. P. falciparum predominates and is chloroquine-resistant. Continuous antimalarial chemoprophylaxis (atovaquone-proguanil, doxycycline, mefloquine, or tafenoquine) is recommended for all travelers, combined with strict mosquito-bite prevention. Seek medical attention urgently for any fever during or up to a year after travel.

Risk
High, all areas, year-round
Species
Mainly P. falciparum
Resistance
Chloroquine-resistant
Prevention
Chemoprophylaxis + bite protection for all travelers

Yellow fever

High

The Central African Republic is yellow-fever endemic and the vaccine is medically recommended for all travelers ≥9 months. A vaccination certificate is also REQUIRED for entry (all arrivals ≥9 months). Vaccinate at least 10 days before arrival; see the country alert above.

Risk
Endemic (vaccine recommended)
Entry rule
Certificate required, ≥9 months
Timing
≥10 days before arrival
Yellow fever vaccine recommendation areas in Africa (CDC).

Dengue

Low

Dengue is present and transmitted by daytime-biting Aedes mosquitoes. Daytime mosquito-bite prevention (repellent, covering clothing) is the main protection; this also reduces other arboviral risks.

Distribution
Present countrywide
Mosquito
Aedes — bites during daytime
Prevention
Daytime bite protection

General prevention

Food & water

Strict food and water precautions are essential. Use bottled or treated water, avoid ice and raw produce, and eat only thoroughly cooked food. Healthcare access is severely limited — carry a personal medical kit and arrange evacuation insurance. Avoid wading or swimming in fresh water (schistosomiasis risk).

Mosquito protection

Aggressive mosquito-bite prevention is essential — chloroquine-resistant malaria risk is high year-round and country-wide, and antimalarial prophylaxis is recommended for all travelers. Dengue and tsetse-fly-borne sleeping sickness are also present. Use DEET or picaridin repellent, cover up, and sleep under an insecticide-treated net.

Sources

Based on CDC Travelers’ Health, CDC Yellow Book, and the Swiss Federal Vaccination Schedule (BAG). Always verify current recommendations before travel.

Visiting more than one country?

Build a combined itinerary and get merged recommendations across all destinations.

Plan an itinerary

This brief is for informational purposes and does not replace personalized medical advice.
Consult a travel medicine specialist 4–8 weeks before departure.